Spherocytosis agglutination & AIHA
Describe:
Blood film showing spherocytosis
Causes of spherocytosis :
1. Hereditary spherocytosis
2. Autoimmune hemolytic anemia ( cold, warm, )z
AIHA may be due to
Idiopathic,
Secondary to another disease, such as an antecedent upper respiratory tract infection,
systemic lupus erythematosus ( SLE ) or malignancy, such as CLL
Medications include quinidine, NSAIDs, alpha methyldopa, and antibiotics such as penicillins,
…
Diagnosis:
positive direct Coombs test
anemia, normal MCV, and hyperbilirubinemia that can be of the conjugated or unconjugated
Treatment:
Corticosteroids and immunoglobulins are two commonly used treatments for warm antibody AIHA. Initial medical treatment consists of prednisone. If ineffective, splenectomy should be considered If refractory to both these therapies, other options include rituximab, danazol,
cyclosphosphamide, azathioprine, or ciclosporin
Describe:
Blood film showing Agglutination
Casuses:
infection with Mycoplasma pneumoniae or Epstein–Barr virus
Pathophysiology:
High igM
Treatment:
No steroid
Avoid cold
Symptomatic treatment
