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Secondary Hypertension & Neurofibromatosis

  • Author: Dr. Hasan Altarrah
  • Published Date: 13/05/2026
  • Last Modified Date:
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  • Reviews: ( 0 Reviews )
  • Category :Internal Medicine
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Additional Information:

  • CC: high blood pressure, in young < 30 years of age

Description

Differential Diagnosis of Secondary Hypertension
  • Cushing syndrome
  • Renal artery stenosis
  • Conn’s syndrome
  • Pheochromocytoma
  • Neurofibromatosis
  • Acromegaly
  • Aortic coarctation
  • Hypo / Hyperthyroidism
  • Obstructive sleep apnea
  • Pregnancy: think of pre-eclampsia
What Will You Do?
  • ECG and Echo
  • Renal Doppler
  • Blood renin / aldosterone ratio
  • Urine metanephrine & normetanephrine
  • Polysomnography
  • 24-hour urine cortisol
  • Basic profile: CBC, RFT, TSH, lipid profile
Neurofibromatosis

Autosomal Dominant

  • Neurofibromas (small bumps in or under skin)
  • Two or more café-au-lait patches: six or more > 15 mm in adults
  • Axillary freckling
  • Lisch nodules: melanocytic hamartomas of iris
Area to Examine
  • Skin
  • Abdomen
  • Chest for crackles (honeycomb lung & fibrosis)
  • Visual acuity: optic glioma or compression
  • Neuropathy and large palpable nerve

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