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Case Details
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Case Details
Ankylosing Spondylitis
Author: Dr. Hasan Altarrah
Published Date: 10/05/2026
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Additional Information:
CC:
back pain or diarrhea
Description
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Description
Area to Examine
Check posture
Fixed kyphoscoliosis
Loss of lumbar lordosis with extension of cervical spine
Reduced chest expansion (< 5 cm increase in girth)
Increased occiput-wall distance (> 5 cm)
Reduced range of movement throughout entire spine
Do Shöber test: positive if expansion is less than 5 cm on maximum forward flexion
Complications
Anterior uveitis
Apical lung fibrosis
Aortic regurgitation
Atrio-ventricular nodal heart block
Arthritis (may be psoriatic arthropathy)
Amyloidosis
Why Did He/She Get Diarrhea?
This is an extra-articular manifestation due to inflammation of the GI tract with possible immune-related involvement
What Will You Do?
X-ray sacroiliac joints
If equivocal or absent findings, do MRI
Blood HLA-B27
Physiotherapy like swimming
Address concerns like work, driving and ADL
NSAIDs like ibuprofen and naproxen (avoid aspirin)
Sulfasalazine for peripheral joint disease
For axial disease:
NSAIDs
Anti-TNF like etanercept
IL-17 inhibitors
Janus kinase inhibitors like tofacitinib
Extra
Ankylosing spondylitis (AS) is a type of seronegative spondyloarthropathy, meaning tests show no presence of rheumatoid factor (RF) antibodies
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